User:Daniel Seeman/Alpha-1-antitrypsin

From Proteopedia

spinqualitylabelsall models PDB ID 1atu1ezxwd.pdb Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1atu, resolution 2.70Å ()
Structural annotation: Resources: CATH : 1Atu002, 1Atu001 InterPro : Ipr000215 Pfam : PF00079 SCOP : d1atu__ UniProt : P01009
Functional annotation: Cellular component: extracellular space extracellular region Biological process: acute-phase response Molecular function: protein binding serine-type endopeptidase inhibitor activity endopeptidase inhibitor activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Alpha-1-antitrypsin (or α1-antitrypsin, A1AT) is an inhibitor of Trypsin. It is a member of the Serine Protease Inhibitor (Serpin) family, and as such undergoes a conformational change where a loop region becomes ordered as a Beta Strand. In this case Trypsin is inhibited when a covalent bond is formed to A1AT. In the case of A1AT, as with most members of the Serpin family, the transition from inactive precursor protein to active complex comes after a cleavage event.

Scenes

See Also

• 1atu
• 1ezx