1ul2
From Proteopedia
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Solution Conformation of alpha-Conotoxin GIC
Overview
Alpha-conotoxin GIC is a 16-residue peptide isolated from the venom of the, cone snail Conus geographus. Alpha-conotoxin GIC potently blocks the, alpha3beta2 subtype of human nicotinic acetylcholine receptor, showing a, high selectivity for neuronal versus muscle subtype [McIntosh, Dowell, Watkins, Garrett, Yoshikami, and Olivera (2002) J. Biol. Chem. 277, 33610-33615]. We have now determined the three-dimensional solution, structure of alpha-conotoxin GIC by NMR spectroscopy. The structure of, alpha-conotoxin GIC is well defined with backbone and heavy atom root mean, square deviations (residues 2-16) of 0.53 A and 0.96 A respectively., Structure and surface comparison of alpha-conotoxin GIC with the other, alpha4/7 subfamily conotoxins reveals unique structural aspects of, alpha-conotoxin GIC. In particular, the structural comparison between, alpha-conotoxins GIC and MII indicates molecular features that may confer, their similar receptor specificity profile, as well as those that provide, the unique binding characteristics of alpha-conotoxin GIC.
About this Structure
1UL2 is a Single protein structure of sequence from [1] with NH2 as ligand. Full crystallographic information is available from OCA.
Reference
Solution conformation of alpha-conotoxin GIC, a novel potent antagonist of alpha3beta2 nicotinic acetylcholine receptors., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem J. 2004 Jun 1;380(Pt 2):347-52. PMID:14992691
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