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User:Kay Owosela
From Proteopedia
Biol 430 Biology Major Partners: Delo Sarr, Mustapha Hussain
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Contents |
Jmol practice
Backbone with ligand
Labeled Ligands in Chain A
Active Site with Amino Acid Residues
Connection between Chain F residue 63 and Chain G residue 319
Stoichiometry
The stoichiometry of Glutamine Synthetase is as follows: Glutamate + NHз + ATP --> Glutamine + ADP + Pi + H+
In this reaction, Glutamate is used as a major reactant and ATP is used for energy to form Glutamine. It should be noted that along with the enzyme, Me+ which can be either manganese or magnesium is used as a catalyst.
This is however, a 2-step reaction. In the first step of this reaction, an intermediate Υ-glutamyl phosphate is formed. The formation of the intermediate is done by phosphoryl transfer an ATP group Y-carboxylate group of glutamate. In the second step of this reaction, NHз attacks the activated intermediate to release the phosphate group yielding Glutamine.
Quarternary Structure Polymerization
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Active Site
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Glutamine Synthetase Symmetry
