1wa5
From Proteopedia
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CRYSTAL STRUCTURE OF THE EXPORTIN CSE1P COMPLEXED WITH ITS CARGO (KAP60P) AND RANGTP
Overview
The nuclear import and export of macromolecular cargoes through nuclear, pore complexes is mediated primarily by carriers such as importin-beta., Importins carry cargoes into the nucleus, whereas exportins carry cargoes, to the cytoplasm. Transport is orchestrated by nuclear RanGTP, which, dissociates cargoes from importins, but conversely is required for cargo, binding to exportins. Here we present the 2.0 A crystal structure of the, nuclear export complex formed by exportin Cse1p complexed with its cargo, (Kap60p) and RanGTP, thereby providing a structural framework for, understanding nuclear protein export and the different functions of RanGTP, in export and import. In the complex, Cse1p coils around both RanGTP and, Kap60p, stabilizing the RanGTP-state and clamping the Kap60p, ... [(full description)]
About this Structure
1WA5 is a [Protein complex] structure of sequences from [Canis familiaris] and [Saccharomyces cerevisiae] with MG and GTP as [ligands]. The following page contains interesting information on the relation of 1WA5 with [Importins]. Full crystallographic information is available from [OCA].
Reference
Structural basis for the assembly of a nuclear export complex., Matsuura Y, Stewart M, Nature. 2004 Dec 16;432(7019):872-7. PMID:15602554
Page seeded by OCA on Mon Oct 29 21:17:55 2007
