1vid
From Proteopedia
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CATECHOL O-METHYLTRANSFERASE
Overview
Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the, central nervous system because it metabolizes catecholamine, neurotransmitters such as dopamine. The enzyme catalyses the transfer of, the methyl group from S-adenosyl-L-methionine (AdoMet) to one hydroxyl, group of catechols. COMT also inactivates catechol-type compounds such as, L-DOPA. With selective inhibitors of COMT in combination with L-DOPA, a, new principle has been realized in the therapy of Parkinson's disease., Here we solve the atomic structure of COMT to 2.0 A resolution, which, provides new insights into the mechanism of the methyl transfer reaction., The co-enzyme-binding domain is strikingly similar to that of an, AdoMet-dependent DNA methylase, indicating that all AdoMet methylases may, have a common structure.
About this Structure
1VID is a Single protein structure of sequence from Rattus norvegicus with MG, SAM and DNC as ligands. Active as Catechol O-methyltransferase, with EC number 2.1.1.6 Full crystallographic information is available from OCA.
Reference
Crystal structure of catechol O-methyltransferase., Vidgren J, Svensson LA, Liljas A, Nature. 1994 Mar 24;368(6469):354-8. PMID:8127373
Page seeded by OCA on Wed Nov 21 04:52:52 2007
