3bys

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Image:3bys.png

Template:STRUCTURE 3bys

Contents

co-crystal structure of Lck and aminopyrimidine amide 10b

Template:ABSTRACT PUBMED 18321037

Disease

Known disease associated with this structure: SCID due to LCK deficiency OMIM:[153390]

About this Structure

3BYS is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation., DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Chai L, Chaffee SC, Deak HL, Epstein LF, Faust T, Gallant P, Gore A, Gu Y, Henkle B, Hsieh F, Huang X, Kim JL, Lee JH, Martin MW, McGowan DC, Metz D, Mohn D, Morgenstern KA, Oliveira-dos-Santos A, Patel VF, Powers D, Rose PE, Schneider S, Tomlinson SA, Tudor YY, Turci SM, Welcher AA, Zhao H, Zhu L, Zhu X, J Med Chem. 2008 Mar 27;51(6):1681-94. Epub 2008 Mar 6. PMID:18321037

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