1w9w
From Proteopedia
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STRUCTURE OF A BETA-1,3-GLUCAN BINDING CBM6 FROM BACILLUS HALODURANS IN COMPLEX WITH LAMINARIHEXAOSE
Overview
Enzymes that hydrolyze insoluble complex polysaccharide structures contain, non-catalytic carbohydrate binding modules (CBMS) that play a pivotal role, in the action of these enzymes against recalcitrant substrates. Family 6, CBMs (CBM6s) are distinct from other CBM families in that these protein, modules contain multiple distinct ligand binding sites, a feature that, makes CBM6s particularly appropriate receptors for the beta-1,3-glucan, laminarin, which displays an extended U-shaped conformation. To, investigate the mechanism by which family 6 CBMs recognize laminarin, we, report the biochemical and structural properties of a CBM6 (designated, BhCBM6) that is located in an enzyme, which is shown, in this work, to, display beta-1,3-glucanase activity. BhCBM6 binds, ... [(full description)]
About this Structure
1W9W is a [Single protein] structure of sequence from [Bacillus halodurans] with NA as [ligand]. Full crystallographic information is available from [OCA].
Reference
Family 6 carbohydrate binding modules recognize the non-reducing end of beta-1,3-linked glucans by presenting a unique ligand binding surface., van Bueren AL, Morland C, Gilbert HJ, Boraston AB, J Biol Chem. 2005 Jan 7;280(1):530-7. Epub 2004 Oct 22. PMID:15501830
Page seeded by OCA on Mon Oct 29 21:21:54 2007
