3f5p
From Proteopedia
Contents |
Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor
Template:ABSTRACT PUBMED 19041240
Disease
Known disease associated with this structure: Intrauterine and postnatal growth retardation OMIM:[147370]
About this Structure
3F5P is a 16 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment., Miller LM, Mayer SC, Berger DM, Boschelli DH, Boschelli F, Di L, Du X, Dutia M, Floyd MB, Johnson M, Kenny CH, Krishnamurthy G, Moy F, Petusky S, Tkach D, Torres N, Wu B, Xu W, Bioorg Med Chem Lett. 2009 Jan 1;19(1):62-6. Epub 2008 Nov 17. PMID:19041240
Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment., Mayer SC, Banker AL, Boschelli F, Di L, Johnson M, Kenny CH, Krishnamurthy G, Kutterer K, Moy F, Petusky S, Ravi M, Tkach D, Tsou HR, Xu W, Bioorg Med Chem Lett. 2008 Jun 15;18(12):3641-5. Epub 2008 Apr 25. PMID:18501599
Page seeded by OCA on Wed Dec 31 10:36:35 2008
Categories: Homo sapiens | Receptor protein-tyrosine kinase | Berger, D M. | Boschelli, D H. | Boschelli, F. | Mayer, S C. | Miller, L M. | Xu, W. | Atp-binding | Cleavage on pair of basic residue | Disease mutation | Glycoprotein | Igf-1r | Membrane | Nucleotide-binding | Phosphoprotein | Polymorphism | Protein-inhibitor complex | Receptor | Transferase | Transmembrane | Tyrosine kinase | Tyrosine-protein kinase
