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1x1z
From Proteopedia
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Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)
Overview
Orotidine-5'-monophosphate decarboxylase (ODCase) has evolved to catalyze a decarboxylation reaction, most probably via a carbanion species at the C6 position of orotidine-5'-monophosphate. We reveal an unusual biochemical pathway of conversion of 6-cyano-uridine-5'-monophosphate by ODCase to barbiturate-5'-monophosphate via perhaps an electrophilic center at the C6 position, leading to inhibition. This potential of ODCase is very useful in the design of novel inhibitors.
About this Structure
1X1Z is a Single protein structure of sequence from Methanothermobacter thermautotrophicus with BMP and GOL as ligands. Active as Orotidine-5'-phosphate decarboxylase, with EC number 4.1.1.23 Full crystallographic information is available from OCA.
Reference
An unprecedented twist to ODCase catalytic activity., Fujihashi M, Bello AM, Poduch E, Wei L, Annedi SC, Pai EF, Kotra LP, J Am Chem Soc. 2005 Nov 2;127(43):15048-50. PMID:16248642
Page seeded by OCA on Wed Nov 21 05:48:00 2007
Categories: Methanothermobacter thermautotrophicus | Orotidine-5'-phosphate decarboxylase | Single protein | Annedi, S.C. | Bello, A.M. | Fujihashi, M. | Kotra, L.P. | Pai, E.F. | Poduch, E. | Wei, L. | BMP | GOL | 6-cyanoump | Barbituric acid ribosyl 5'-monophosphate (bmp) | Orotidine 5'-monophosphate decarboxylase (odcase)
