1sa4

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Image:1sa4.png

Template:STRUCTURE 1sa4

human protein farnesyltransferase complexed with FPP and R115777

Template:ABSTRACT PUBMED 15170324

About this Structure

1SA4 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Reid TS, Beese LS. Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity. Biochemistry. 2004 Jun 8;43(22):6877-84. PMID:15170324 doi:10.1021/bi049723b

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