1o9u
From Proteopedia
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GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE
Overview
Glycogen synthase kinase 3beta (GSK3beta) is a serine/threonine kinase, involved in insulin, growth factor and Wnt signalling. In Wnt signalling, GSK3beta is recruited to a multiprotein complex via interaction with axin, where it hyperphosphorylates beta-catenin, marking it for ubiquitylation, and destruction. We have now determined the crystal structure of GSK3beta, in complex with a minimal GSK3beta-binding segment of axin, at 2.4 A, resolution. The structure confirms the co-localization of the binding, sites for axin and FRAT in the C-terminal domain of GSK3beta, but reveals, significant differences in the interactions made by axin and FRAT, mediated by conformational plasticity of the 285-299 loop in GSK3beta., Detailed comparison of the axin and FRAT GSK3beta complexes allows the, ... [(full description)]
About this Structure
1O9U is a [Protein complex] structure of sequences from [Homo sapiens] with ADZ as [ligand]. Active as [[1]], with EC number [2.7.1.37]. Full crystallographic information is available from [OCA].
Reference
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex., Dajani R, Fraser E, Roe SM, Yeo M, Good VM, Thompson V, Dale TC, Pearl LH, EMBO J. 2003 Feb 3;22(3):494-501. PMID:12554650
Page seeded by OCA on Mon Oct 29 21:27:14 2007
Categories: Homo sapiens | Protein complex | Dajani, R. | Pearl, L.H. | Roe, S.M. | ADZ | Anti-oncogene | Apoptosis | Developmental protein | Insulin pathway | Kinase | Multigene family | Phosphorylation | Phosphorylation; alternative splicing | Serine/threonine -protein kinase; atp-binding | Transferase