1xe3

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spinqualitylabelsall models 1xe3, resolution 2.24Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of purine nucleoside phosphorylase DeoD from Bacillus anthracis

Overview

Protein structures from the causative agent of anthrax (Bacillus, anthracis) are being determined as part of a structural genomics, programme. Amongst initial candidates for crystallographic analysis are, enzymes involved in nucleotide biosynthesis, since these are recognized as, potential targets in antibacterial therapy. Purine nucleoside, phosphorylase is a key enzyme in the purine-salvage pathway. The crystal, structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has, been solved by molecular replacement at 2.24 A resolution and refined to, an R factor of 18.4%. This is the first report of a DeoD structure from a, Gram-positive bacterium.

About this Structure

1XE3 is a Single protein structure of sequence from Bacillus anthracis with CL as ligand. Active as Purine-nucleoside phosphorylase, with EC number 2.4.2.1 Full crystallographic information is available from OCA.

Reference

Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis., Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005 May 1;61(Pt, 5):459-62. Epub 2005 Apr 9. PMID:16511068

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