1xnq

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Image:1xnq.gif

1xnq, resolution 3.05Å

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Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center

Overview

Here we report the crystal structures of I.C and I.A wobble base pairs in, the context of the ribosomal decoding center, clearly showing that the I.A, base pair is of an I(anti).A(anti) conformation, as predicted by Crick., Additionally, the structures enable the observation of changes in the, anticodon to allow purine-purine base pairing, the 'widest' base pair, geometry allowed in the wobble position.

About this Structure

1XNQ is a Protein complex structure of sequences from Thermus thermophilus with PAR, MG and ZN as ligands. Full crystallographic information is available from OCA.

Reference

Structure of a purine-purine wobble base pair in the decoding center of the ribosome., Murphy FV 4th, Ramakrishnan V, Nat Struct Mol Biol. 2004 Dec;11(12):1251-2. Epub 2004 Nov 21. PMID:15558050

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