1xog
From Proteopedia
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N9 Tern Influenza neuraminidase complexed with a 2,5-Disubstituted tetrahydrofuran-5-carboxylic acid
Overview
(+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-methoxycarbonyl]tetr, ahydrofuran-5-carboxylic acid (9) and, (+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-(4'-imidazolyl)]tetr, ahydrofuran 5-carboxylic acid (14) were synthesized as inhibitors of, influenza neuraminidase (NA). Both compounds 9 and 14 inhibit influenza NA, A with an IC(50) of about 0.5 microM and NA B with an IC(50) of 1.0, microM.
About this Structure
1XOG is a Single protein structure of sequence from Influenza a virus with MAN, NAG and ABW as ligands. Active as Exo-alpha-sialidase, with EC number 3.2.1.18 Full crystallographic information is available from OCA.
Reference
Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core., Wang GT, Wang S, Gentles R, Sowin T, Maring CJ, Kempf DJ, Kati WM, Stoll V, Stewart KD, Laver G, Bioorg Med Chem Lett. 2005 Jan 3;15(1):125-8. PMID:15582424
Page seeded by OCA on Wed Nov 21 06:14:17 2007
Categories: Exo-alpha-sialidase | Influenza a virus | Single protein | Gentles, R. | Kati, W.M. | Kempf, D.J. | Laver, G. | Maring, C.J. | Sowin, T. | Stewart, K.D. | Stoll, V. | Wang, G.T. | Wang, S. | ABW | MAN | NAG | Influenza | Neuraminidase | Tetrahydrofuran inhibitors
