1s63

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Image:1s63.png

Template:STRUCTURE 1s63

Human protein farnesyltransferase complexed with L-778,123 and FPP

Template:ABSTRACT PUBMED 15248757

About this Structure

1S63 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Reid TS, Long SB, Beese LS. Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes. Biochemistry. 2004 Jul 20;43(28):9000-8. PMID:15248757 doi:10.1021/bi049280b

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