1xuq
From Proteopedia
|
Crystal Structure of SodA-1 (BA4499) from Bacillus anthracis at 1.8A Resolution.
Overview
The BA4499 and BA5696 genes of Bacillus anthracis encode proteins, homologous to manganese superoxide dismutase, suggesting that this, organism has an expanded repertoire of antioxidant proteins. Differences, in metal specificity and quaternary structure between the dismutases of, prokaryotes and higher eukaryotes may be exploited in the development of, therapeutic antibacterial compounds. Here, the crystal structure of two Mn, superoxide dismutases from B. anthracis solved to high resolution are, reported. Comparison of their structures reveals that a highly conserved, residue near the active centre is substituted in one of the proteins and, that this is a characteristic feature of superoxide dismutases from the B., cereus/B. anthracis/B. thuringiensis group of organisms.
About this Structure
1XUQ is a Single protein structure of sequence from Bacillus anthracis with MN as ligand. Active as Superoxide dismutase, with EC number 1.15.1.1 Full crystallographic information is available from OCA.
Reference
Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre., Boucher IW, Kalliomaa AK, Levdikov VM, Blagova EV, Fogg MJ, Brannigan JA, Wilson KS, Wilkinson AJ, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):621-4. Epub 2005 Jun 15. PMID:16511113
Page seeded by OCA on Wed Nov 21 06:21:37 2007
