1w50

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spinqualitylabelsall models PDB ID 1w50 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1w50, resolution 1.75Å ()
Ligands:
Activity:	Memapsin 2, with EC number 3.4.23.46
Related:	1fkn, 1m4h, 1py1, 1sgz, 1ujj, 1ujk, 1w51
Structural annotation: Resources: CATH : 1W50A01, 1W50A02 InterPro : Ipr001969, Ipr001461, Ipr009007, Ipr009120, Ipr009119 Pfam : PF00026 SCOP : d1w50a_ UniProt : P56817
Functional annotation: Cellular component: Golgi apparatus endosome integral to membrane integral to plasma membrane membrane Biological process: proteolysis beta-amyloid metabolic process membrane protein ectodomain proteolysis Molecular function: aspartic-type signal peptidase activity aspartic-type endopeptidase activity pepsin A activity peptidase activity beta-aspartyl-peptidase activity hydrolase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

APO STRUCTURE OF BACE (BETA SECRETASE)

Template:ABSTRACT PUBMED 15451669

About this Structure

1W50 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Patel S, Vuillard L, Cleasby A, Murray CW, Yon J. Apo and inhibitor complex structures of BACE (beta-secretase). J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669 doi:10.1016/j.jmb.2004.08.018

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