1o7i
From Proteopedia
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CRYSTAL STRUCTURE OF A SINGLE STRANDED DNA BINDING PROTEIN
Overview
Information processing pathways such as DNA replication are conserved in, eukaryotes and archaea and are significantly different from those found in, bacteria. Single-stranded DNA-binding (SSB) proteins (or replication, protein A, RPA, in eukaryotes) play a central role in many of these, pathways. However, whilst euryarchaea have a eukaryotic-type RPA, homologue, crenarchaeal SSB proteins appear much more similar to the, bacterial proteins, with a single OB fold for DNA binding and a flexible, C-terminal tail that is implicated in protein-protein interactions. We, have determined the crystal structure of the SSB protein from the, crenarchaeote Sulfolobus solfataricus to 1.26 A. The structure shows a, striking and unexpected similarity to the DNA-binding domains of human, RPA, providing ... [(full description)]
About this Structure
1O7I is a [Single protein] structure of sequence from [Sulfolobus solfataricus] with SO4 as [ligand]. Full crystallographic information is available from [OCA].
Reference
Insights into ssDNA recognition by the OB fold from a structural and thermodynamic study of Sulfolobus SSB protein., Kerr ID, Wadsworth RI, Cubeddu L, Blankenfeldt W, Naismith JH, White MF, EMBO J. 2003 Jun 2;22(11):2561-70. PMID:12773373
Page seeded by OCA on Mon Oct 29 21:30:45 2007
