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1y0f

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Image:1y0f.gif

1y0f, resolution 5.16Å

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The structure of collagen type I. Single type I collagen molecule

Overview

The fibrous collagens are ubiquitous in animals and form the structural, basis of all mammalian connective tissues, including those of the heart, vasculature, skin, cornea, bones, and tendons. However, in comparison with, what is known of their production, turnover and physiological structure, very little is understood regarding the three-dimensional arrangement of, collagen molecules in naturally occurring fibrils. This knowledge may, provide insight into key biological processes such as fibrillo-genesis and, tissue remodeling and into diseases such as heart disease and cancer. Here, we present a crystallographic determination of the collagen type I, supermolecular structure, where the molecular conformation of each, collagen segment found within the naturally occurring crystallographic, unit cell has been defined (P1, a approximately 40.0 A, b approximately, 27.0 A, c approximately 678 A, alpha approximately 89.2 degrees , beta, approximately 94.6 degrees , gamma approximately 105.6 degrees ;, reflections: 414, overlapping, 232, and nonoverlapping, 182; resolution, 5.16 A axial and 11.1 A equatorial). This structure shows that the, molecular packing topology of the collagen molecule is such that packing, neighbors are arranged to form a supertwisted (discontinuous) right-handed, microfibril that interdigitates with neighboring microfibrils. This, interdigitation establishes the crystallographic superlattice, which is, formed of quasihexagonally packed collagen molecules. In addition, the, molecular packing structure of collagen shown here provides information, concerning the potential modes of action of two prominent molecules, involved in human health and disease: decorin and the Matrix, Metallo-Proteinase (MMP) collagenase.

About this Structure

1Y0F is a Protein complex structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Microfibrillar structure of type I collagen in situ., Orgel JP, Irving TC, Miller A, Wess TJ, Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9001-5. Epub 2006 Jun 2. PMID:16751282

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