2flb

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Image:2flb.png

Template:STRUCTURE 2flb

Contents

Discovery of a Novel Hydroxy Pyrazole Based Factor IXa Inhibitor

Template:ABSTRACT PUBMED 16487703

Disease

Known disease associated with this structure: Factor VII deficiency OMIM:[227500], Myocardial infarction, decreased susceptibility to OMIM:[227500]

About this Structure

2FLB is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Vijaykumar D, Sprengeler PA, Shaghafi M, Spencer JR, Katz BA, Yu C, Rai R, Young WB, Schultz B, Janc J. Discovery of novel hydroxy pyrazole based factor IXa inhibitor. Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. Epub 2006 Feb 17. PMID:16487703 doi:10.1016/j.bmcl.2006.01.123

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