2hh4

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Image:2hh4.png

Template:STRUCTURE 2hh4

Contents

NMR structure of human insulin mutant GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 structures

Template:ABSTRACT PUBMED 16762918

Disease

Known disease associated with this structure: Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]

About this Structure

2HH4 is a 2 chains structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Hua QX, Nakagawa S, Hu SQ, Jia W, Wang S, Weiss MA. Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain. J Biol Chem. 2006 Aug 25;281(34):24900-9. Epub 2006 Jun 8. PMID:16762918 doi:http://dx.doi.org/10.1074/jbc.M602691200

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