2bka

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CC3(TIP30)CRYSTAL STRUCURE

Overview

CC3 (TIP30) is a protein with pro-apoptotic and anti-metastatic, properties. The tumor suppressor effect of CC3 has been suggested to, result from inhibition of nuclear transport by binding to importin betas, or by regulating transcription through interaction in a complex with, co-activator independent of AF-2 function (CIA) and the c-myc gene., Previous biochemical studies indicated that CC3 has protein kinase, activity, and a structural similarity to cAMP-dependent protein kinase, catalytic subunit was proposed. By contrast, bioinformatics studies, suggested a relationship of CC3 to the short chain dehydrogenase reductase, family. To clarify details of the CC3 structural family and ligand binding, properties, we have determined the crystal structure of CC3 at 1.7-A, resolution. CC3 has ... [(full description)]

About this Structure

2BKA is a [Single protein] structure of sequence from [Homo sapiens] with SO4, NDP, PE8 and GOL as [ligands]. Full crystallographic information is available from [OCA].

Reference

Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor., El Omari K, Bird LE, Nichols CE, Ren J, Stammers DK, J Biol Chem. 2005 May 6;280(18):18229-36. Epub 2005 Feb 22. PMID:15728189

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