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spinqualitylabelsall models 2bk3, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

HUMAN MONOAMINE OXIDASE B IN COMPLEX WITH FARNESOL

Overview

Several reversible inhibitors selective for human monoamine oxidase B (MAO, B) that do not inhibit MAO A have been described in the literature. The, following compounds: 8-(3-chlorostyryl)caffeine, 1,4-diphenyl-2-butene, and trans,trans-farnesol are shown to inhibit competitively human, horse, rat, and mouse MAO B with K(i) values in the low micromolar range but are, without effect on either bovine or sheep MAO B or human MAO A. In, contrast, the reversible competitive inhibitor isatin binds to all known, MAO B and MAO A with similar affinities. Sequence alignments and the, crystal structures of human MAO B in complex with 1,4-diphenyl-2-butene or, with trans,trans-farnesol provide molecular insights into these, specificities. These inhibitors span the substrate and entrance cavities, ... [(full description)]

About this Structure

2BK3 is a [Single protein] structure of sequence from [Homo sapiens] with FAD and FOH as [ligands]. Active as [[1]], with EC number [1.4.3.4]. Full crystallographic information is available from [OCA].

Reference

Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors., Hubalek F, Binda C, Khalil A, Li M, Mattevi A, Castagnoli N, Edmondson DE, J Biol Chem. 2005 Apr 22;280(16):15761-6. Epub 2005 Feb 14. PMID:15710600

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