1owe

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Template:STRUCTURE 1owe

Contents 1 Substituted 2-Naphthamidine inhibitors of urokinase 2 Disease 3 About this Structure 4 Reference

Substituted 2-Naphthamidine inhibitors of urokinase

Template:ABSTRACT PUBMED 14711304

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

1OWE is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Wendt MD, Rockway TW, Geyer A, McClellan W, Weitzberg M, Zhao X, Mantei R, Nienaber VL, Stewart K, Klinghofer V, Giranda VL. Identification of novel binding interactions in the development of potent, selective 2-naphthamidine inhibitors of urokinase. Synthesis, structural analysis, and SAR of N-phenyl amide 6-substitution. J Med Chem. 2004 Jan 15;47(2):303-24. PMID:14711304 doi:10.1021/jm0300072

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