1yi8

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Image:1yi8.gif

1yi8, resolution 2.1Å

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Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp

Overview

The most divergent of two tryptophanyl tRNA synthetases (TrpRS II) found, in Deinococcus radiodurans interacts with a nitric oxide synthase protein, that produces 4-nitro-tryptophan (4-NRP). TrpRS II efficiently charges, transfer RNA(Trp) with 4-NRP and 5-hydroxy-tryptophan (5-HRP). The crystal, structures of TrpRS II bound to tryptophan and 5-HRP reveal residue, substitutions that accommodate modified indoles. A class of auxiliary, bacterial TrpRSs conserve this capacity to charge tRNA with nonstandard, amino acids.

About this Structure

1YI8 is a Single protein structure of sequence from Deinococcus radiodurans r1 with TRP as ligand. Full crystallographic information is available from OCA.

Reference

Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan., Buddha MR, Crane BR, Nat Struct Mol Biol. 2005 Mar;12(3):274-5. Epub 2005 Feb 20. PMID:15723076

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