2bkf

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Image:2bkf.gif

2bkf, resolution 1.56Å

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STRUCTURE OF THE PB1 DOMAIN OF NBR1

Overview

The scaffold protein NBR1 is involved in signal transmission downstream of, the serine/protein kinase from the giant muscle protein titin. Its, N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating, protein-protein interactions with both titin kinase and with another, scaffold protein, p62. We have determined the crystal structure of the PB1, domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with, two negatively charged residue clusters. We provide a structural, perspective on the involvement of NBR1 in the titin kinase signalling, pathway.

About this Structure

2BKF is a [Single protein] structure of sequence from [Homo sapiens] with GOL as [ligand]. Full crystallographic information is available from [OCA].

Reference

Crystal structure of the PB1 domain of NBR1., Muller S, Kursula I, Zou P, Wilmanns M, FEBS Lett. 2006 Jan 9;580(1):341-4. Epub 2005 Dec 19. PMID:16376336

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