2a45

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Image:2a45.png

Template:STRUCTURE 2a45

Crystal structure of the complex between thrombin and the central "E" region of fibrin

Template:ABSTRACT PUBMED 16533041

About this Structure

2A45 is a 12 chains structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 1qvh. The November 2006 RCSB PDB Molecule of the Month feature on Fibrin by David S. Goodsell is 10.2210/rcsb_pdb/mom_2006_11. Full crystallographic information is available from OCA.

Reference

  • Pechik I, Yakovlev S, Mosesson MW, Gilliland GL, Medved L. Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly. Biochemistry. 2006 Mar 21;45(11):3588-97. PMID:16533041 doi:10.1021/bi0525369
  • Pechik I, Madrazo J, Mosesson MW, Hernandez I, Gilliland GL, Medved L. Crystal structure of the complex between thrombin and the central "E" region of fibrin. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2718-23. Epub 2004 Feb 20. PMID:14978285 doi:10.1073/pnas.0303440101

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