1ym5

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spinqualitylabelsall models 1ym5, resolution 2.05Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily.

Overview

In the Pseudomonas bacterial genomes, the PhzF proteins are involved in, the production of phenazine derivative antibiotic and antifungal, compounds. The PhzF superfamily however also encompasses proteins in all, genomes from bacteria to eukaryotes, for which no function has been, assigned. We have determined the three dimensional crystal structure at, 2.05 A resolution of YHI9, the yeast member of the PhzF family. YHI9 has a, fold similar to bacterial diaminopimelate epimerase, revealing a bimodular, structure with an internal symmetry. Residue conservation identifies a, putative active site at the interface between the two domains. Evolution, of this protein by gene duplication, gene fusion and domain swapping from, an ancestral gene containing the "hot dog" fold, identifies the protein as, a "kinked double hot dog" fold.

About this Structure

1YM5 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily., Liger D, Quevillon-Cheruel S, Sorel I, Bremang M, Blondeau K, Aboulfath I, Janin J, van Tilbeurgh H, Leulliot N, Proteins. 2005 Sep 1;60(4):778-86. PMID:16021630

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