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6pax

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Revision as of 15:56, 16 February 2009 by OCA (Talk | contribs)
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Image:6pax.png

Template:STRUCTURE 6pax

Contents

CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS

Template:ABSTRACT PUBMED 10346815

Disease

Known disease associated with this structure: Aniridia OMIM:[607108], Cataract with late-onset corneal dystrophy OMIM:[607108], Coloboma of optic nerve OMIM:[607108], Coloboma, ocular OMIM:[607108], Ectopia pupillae OMIM:[607108], Foveal hyperplasia OMIM:[607108], Gillespie synd OMIM:[607108], Keratitis OMIM:[607108], Morning glory disc anomaly OMIM:[607108], Optic nerve hypoplasia OMIM:[607108], Peters anomaly OMIM:[607108]

About this Structure

6PAX is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Xu HE, Rould MA, Xu W, Epstein JA, Maas RL, Pabo CO. Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev. 1999 May 15;13(10):1263-75. PMID:10346815

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