This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1yv3
From Proteopedia
|
The structural basis of blebbistatin inhibition and specificity for myosin II
Overview
Molecular motors play a central role in cytoskeletal-mediated cellular, processes and thus present an excellent target for cellular control by, pharmacological agents. Yet very few such compounds have been found. We, report here the structure of blebbistatin, which inhibits specific myosin, isoforms, bound to the motor domain of Dictyostelium discoideum myosin II., This reveals the structural basis for its specificity and provides insight, into the development of new agents.
About this Structure
1YV3 is a Single protein structure of sequence from Dictyostelium discoideum with MG, VO4, ADP, BIT and EDO as ligands. Full crystallographic information is available from OCA.
Reference
The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603
Page seeded by OCA on Wed Nov 21 07:04:24 2007
Categories: Dictyostelium discoideum | Single protein | Allingham, J.S. | Rayment, I. | Smith, R. | ADP | BIT | EDO | MG | VO4 | Blebbistatin | Metastable state | Myosin | Myosin ii inhibitor | Myosin-inhibitor complex
