3b2r
From Proteopedia
Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil
Template:ABSTRACT PUBMED 17959709
About this Structure
3B2R is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wang H, Ye M, Robinson H, Francis SH, Ke H. Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Mol Pharmacol. 2008 Jan;73(1):104-10. Epub 2007 Oct 24. PMID:17959709 doi:10.1124/mol.107.040212
Page seeded by OCA on Mon Feb 16 18:14:04 2009
Categories: 3',5'-cyclic-GMP phosphodiesterase | Homo sapiens | Hengming, K. | Howard, R. | Huanchen, W. | Mengchun, Y. | Sharron, H F. | Allosteric enzyme | Alternative splicing | Cgmp phosphodiesterase | Cgmp-binding | Hydrolase | Levitratm. | Magnesium | Metal-binding | Nucleotide-binding | Pde5-inhibitor potency | Phosphorylation | Polymorphism | Sildenafil | Vardenafil | Zinc