2r2l

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Image:2r2l.png

Template:STRUCTURE 2r2l

Structure of Farnesyl Protein Transferase bound to PB-93

Template:ABSTRACT PUBMED 17606674

About this Structure

2R2L is a 2 chains structure of sequences from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Van Voorhis WC, Rivas KL, Bendale P, Nallan L, Horney C, Barrett LK, Bauer KD, Smart BP, Ankala S, Hucke O, Verlinde CL, Chakrabarti D, Strickland C, Yokoyama K, Buckner FS, Hamilton AD, Williams DK, Lombardo LJ, Floyd D, Gelb MH. Efficacy, pharmacokinetics, and metabolism of tetrahydroquinoline inhibitors of Plasmodium falciparum protein farnesyltransferase. Antimicrob Agents Chemother. 2007 Oct;51(10):3659-71. Epub 2007 Jul 2. PMID:17606674 doi:10.1128/AAC.00246-07

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