This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1zbd
From Proteopedia
|
STRUCTURAL BASIS OF RAB EFFECTOR SPECIFICITY: CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAB3A COMPLEXED WITH THE EFFECTOR DOMAIN OF RABPHILIN-3A
Overview
The small G protein Rab3A plays an important role in the regulation of, neurotransmitter release. The crystal structure of activated, Rab3A/GTP/Mg2+ bound to the effector domain of rabphilin-3A was solved to, 2.6 A resolution. Rabphilin-3A contacts Rab3A in two distinct areas. The, first interface involves the Rab3A switch I and switch II regions, which, are sensitive to the nucleotide-binding state of Rab3A. The second, interface consists of a deep pocket in Rab3A that interacts with a SGAWFF, structural element of rabphilin-3A. Sequence and structure analysis, and, biochemical data suggest that this pocket, or Rab, complementarity-determining region (RabCDR), establishes a specific, interaction between each Rab protein and its effectors. RabCDRs could be, major determinants of effector specificity during vesicle trafficking and, fusion.
About this Structure
1ZBD is a Protein complex structure of sequences from Rattus norvegicus with ZN, MG and GTP as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A., Ostermeier C, Brunger AT, Cell. 1999 Feb 5;96(3):363-74. PMID:10025402
Page seeded by OCA on Wed Nov 21 07:21:49 2007
Categories: Protein complex | Rattus norvegicus | Brunger, A.T. | Ostermeier, C. | GTP | MG | ZN | Effector | G protein | Rab protein | Rab3a | Rabcdr | Rabphilin | Synaptic exocytosis
