1zrt

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spinqualitylabelsall models 1zrt, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Rhodobacter capsulatus cytochrome bc1 complex with stigmatellin bound

Overview

Ubihydroquinone: cytochrome (cyt)c oxidoreductase, or cyt bc (1), is a, widespread, membrane integral enzyme that plays a crucial role during, photosynthesis and respiration. It is one of the major contributors of the, electrochemical proton gradient, which is subsequently used for ATP, synthesis. The simplest form of the cyt bc (1) is found in bacteria, and, it contains only the three ubiquitously conserved catalytic subunits: the, Fe-S protein, cyt b and cyt c (1). Here we present a preliminary X-ray, structure of Rhodobacter capsulatus cyt bc (1) at 3.8 A and compare it to, the available structures of its homologues from mitochondria and, chloroplast. Using the bacterial enzyme structure, we highlight the, structural similarities and differences that are found among the three, catalytic subunits between the members of this family of enzymes. In, addition, we discuss the locations of currently known critical mutations, and their implications in terms of the cyt bc (1) catalysis.

About this Structure

1ZRT is a Protein complex structure of sequences from Rhodobacter capsulatus with HEM, SMA, HEC and FES as ligands. Active as Ubiquinol--cytochrome-c reductase, with EC number 1.10.2.2 Full crystallographic information is available from OCA.

Reference

X-Ray Structure of Rhodobacter Capsulatus Cytochrome bc (1): Comparison with its Mitochondrial and Chloroplast Counterparts., Berry EA, Huang LS, Saechao LK, Pon NG, Valkova-Valchanova M, Daldal F, Photosynth Res. 2004;81(3):251-75. PMID:16034531

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