This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1afi
From Proteopedia
|
STRUCTURE OF THE REDUCED FORM OF MERP, THE PERIPLASMIC PROTEIN FROM THE BACTERIAL MERCURY DETOXIFICATION SYSTEM, NMR, 20 STRUCTURES
Overview
Bacteria carrying plasmids with the mer operon, which encodes the proteins, responsible for the bacterial mercury detoxification system, have the, ability to transport Hg(II) across the cell membrane into the cytoplasm, where it is reduced to Hg(0). This is significant because metallic mercury, is relatively nontoxic and volatile and thus can be passively eliminated., The structures of the reduced and mercury-bound forms of merP, the, periplasmic protein, which binds Hg(II) and transfers it to the membrane, transport protein merT, have been determined in aqueous solution by, multidimensional NMR spectroscopy. The 72-residue merP protein has a, betaalpha betabeta alphabeta fold with the two alpha helices overlaying a, four-strand antiparallel beta sheet. Structural differences between the, ... [(full description)]
About this Structure
1AFI is a [Single protein] structure of sequence from [Shigella flexneri]. Full crystallographic information is available from [OCA].
Reference
Structures of the reduced and mercury-bound forms of MerP, the periplasmic protein from the bacterial mercury detoxification system., Steele RA, Opella SJ, Biochemistry. 1997 Jun 10;36(23):6885-95. PMID:9188683
Page seeded by OCA on Mon Oct 29 21:40:45 2007
