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2hyy

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This article has been automatically seeded. Changes to this page should pertain to the PDB entry only and not to the protein or biomolecule in general.

Image:2hyy.png

2hyy, resolution 2.40Å ()

Ligands:

Gene:

ABL1 (Homo sapiens)

Activity:

Non-specific protein-tyrosine kinase, with EC number 2.7.10.2

Related:

1iep, 1fpu

Structural annotation:
Resources:	InterPro : Ipr015015, Ipr000980, Ipr000719, Ipr011009, Ipr001245, Ipr008266, Ipr001452 Pfam : PF07714 UniProt : P00519

Functional annotation:
Cellular component:	cytoplasm nucleus cytoskeleton
Biological process:	actin cytoskeleton organization and biogenesis protein amino acid phosphorylation peptidyl-tyrosine phosphorylation intracellular signaling cascade mismatch repair DNA damage response, signal transduction resulting in induction of apoptosis S-phase-specific transcription in mitotic cell cycle regulation of transcription, DNA-dependent cell adhesion protein modification process
Molecular function:	ATP binding transferase activity protein-tyrosine kinase activity protein C-terminus binding nucleotide binding manganese ion binding magnesium ion binding protein kinase activity kinase activity protein binding DNA binding metal ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1 Human Abl kinase domain in complex with imatinib (STI571, Glivec)
2 Disease
3 About this Structure
4 Reference

Human Abl kinase domain in complex with imatinib (STI571, Glivec)

Template:ABSTRACT PUBMED 17164530

Disease

Known disease associated with this structure: Leukemia, Philadelphia chromosome-positive, resistant to imatinib OMIM:[189980]

About this Structure

2HYY is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Cowan-Jacob SW, Fendrich G, Floersheimer A, Furet P, Liebetanz J, Rummel G, Rheinberger P, Centeleghe M, Fabbro D, Manley PW. Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):80-93. Epub 2006, Dec 13. PMID:17164530 doi:http://dx.doi.org/10.1107/S0907444906047287

Page seeded by OCA on Tue Feb 17 00:39:09 2009

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2hyy

From Proteopedia

Contents

Human Abl kinase domain in complex with imatinib (STI571, Glivec)

Disease

About this Structure

Reference

Proteopedia Page Contributors and Editors (what is this?)

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