2a2j

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spinqualitylabelsall models 2a2j, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis

Overview

The three-dimensional structure of Rv2607, a putative pyridoxine, 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been, determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core, domain similar to known PNPOx structures with a flavin mononucleotide, (FMN) cofactor. Electron density for two FMN at the dimer interface is, weak despite the bright yellow color of the protein solution and crystal., The shape and size of the putative binding pocket is markedly different, from that of members of the PNPOx family, which may indicate some, significant changes in the FMN binding mode of this protein relative to, members of the family.

About this Structure

2A2J is a Single protein structure of sequence from Mycobacterium tuberculosis. Active as Pyridoxal 5'-phosphate synthase, with EC number 1.4.3.5 Full crystallographic information is available from OCA.

Reference

Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis., Pedelacq JD, Rho BS, Kim CY, Waldo GS, Lekin TP, Segelke BW, Rupp B, Hung LW, Kim SI, Terwilliger TC, Proteins. 2006 Mar 15;62(3):563-9. PMID:16374842

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