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1jlb

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Image:1jlb.png

Template:STRUCTURE 1jlb

CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

Template:ABSTRACT PUBMED 11575933

About this Structure

1JLB is a 2 chains structure of sequences from Human immunodeficiency virus type 1 (isolate hxb2). The September 2002 RCSB PDB Molecule of the Month feature on Reverse Transcriptase by David S. Goodsell is 10.2210/rcsb_pdb/mom_2002_9. Full crystallographic information is available from OCA.

Reference

  • Ren J, Nichols C, Bird L, Chamberlain P, Weaver K, Short S, Stuart DI, Stammers DK. Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors. J Mol Biol. 2001 Sep 28;312(4):795-805. PMID:11575933 doi:http://dx.doi.org/10.1006/jmbi.2001.4988

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