2c1p
From Proteopedia
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FAB-FRAGMENT OF ENANTIOSELECTIVE ANTIBODY COMPLEXED WITH FINROZOLE
Overview
Enantioselective antibodies can separate the enantiomers of a chiral, compound in a highly specific manner. We have recently reported the, cloning and applications of a recombinant Fab-fragment, ENA11His, in the, enantioseparation of a drug candidate, finrozole, which contains two, chiral centers. Here, the crystal structures of this enantioselective, antibody Fab-fragment are determined in the absence of the hapten at a, resolution of 2.75 A, and in the presence of the hapten at 2.05 A, resolution. The conformation of the protein was found to be similar in, both free and complex forms. The hapten molecule was tightly bound in a, deep cleft between the light and heavy chains of the Fab-fragment. The, complex structure also allowed us to describe the molecular basis for, enantioselectivity ... [(full description)]
About this Structure
2C1P is a [Single protein] structure of sequence from [Mus musculus] and [Mus musculus] with FNZ as [ligand]. Full crystallographic information is available from [OCA].
Reference
Crystal structures of an enantioselective fab-fragment in free and complex forms., Parkkinen T, Nevanen TK, Koivula A, Rouvinen J, J Mol Biol. 2006 Mar 24;357(2):471-80. Epub 2006 Jan 3. PMID:16427081
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