3bxq

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Image:3bxq.png

Template:STRUCTURE 3bxq

The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition

Template:ABSTRACT PUBMED 18332129

About this Structure

3BXQ is a 4 chains structure. Full crystallographic information is available from OCA.

Reference

  • Hua QX, Nakagawa SH, Jia W, Huang K, Phillips NB, Hu SQ, Weiss MA. Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications. J Biol Chem. 2008 May 23;283(21):14703-16. Epub 2008 Mar 10. PMID:18332129 doi:10.1074/jbc.M800313200

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