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2po5

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Revision as of 03:40, 17 February 2009 by OCA (Talk | contribs)
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Image:2po5.png

Template:STRUCTURE 2po5

Contents

Crystal structure of human ferrochelatase mutant with His 263 replaced by Cys

Template:ABSTRACT PUBMED 17567154

Disease

Known disease associated with this structure: Protoporphyria, erythropoietic, autosomal dominant OMIM:[612386], Protoporphyria, erythropoietic, autosomal recessive OMIM:[612386]

About this Structure

2PO5 is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Dailey HA, Wu CK, Horanyi P, Medlock AE, Najahi-Missaoui W, Burden AE, Dailey TA, Rose J. Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis. Biochemistry. 2007 Jul 10;46(27):7973-9. Epub 2007 Jun 14. PMID:17567154 doi:10.1021/bi700151f
  • Wu CK, Dailey HA, Rose JP, Burden A, Sellers VM, Wang BC. The 2.0 A structure of human ferrochelatase, the terminal enzyme of heme biosynthesis. Nat Struct Biol. 2001 Feb;8(2):156-60. PMID:11175906 doi:10.1038/84152
  • Burden AE, Wu C, Dailey TA, Busch JL, Dhawan IK, Rose JP, Wang B, Dailey HA. Human ferrochelatase: crystallization, characterization of the [2Fe-2S] cluster and determination that the enzyme is a homodimer. Biochim Biophys Acta. 1999 Nov 16;1435(1-2):191-7. PMID:10561552

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