2iwu

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Image:2iwu.png

Template:STRUCTURE 2iwu

ANALOGUES OF RADICICOL BOUND TO THE ATP-BINDING SITE OF HSP90

Template:ABSTRACT PUBMED 17114002

About this Structure

2IWU is a 1 chain structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

  • Proisy N, Sharp SY, Boxall K, Connelly S, Roe SM, Prodromou C, Slawin AM, Pearl LH, Workman P, Moody CJ. Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol. Chem Biol. 2006 Nov;13(11):1203-15. PMID:17114002 doi:10.1016/j.chembiol.2006.09.015

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