3efk

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Image:3efk.png

Template:STRUCTURE 3efk

Contents

Structure of c-Met with pyrimidone inhibitor 50

Template:ABSTRACT PUBMED 18763753

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

3EFK is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • D'Angelo ND, Bellon SF, Booker SK, Cheng Y, Coxon A, Dominguez C, Fellows I, Hoffman D, Hungate R, Kaplan-Lefko P, Lee MR, Li C, Liu L, Rainbeau E, Reider PJ, Rex K, Siegmund A, Sun Y, Tasker AS, Xi N, Xu S, Yang Y, Zhang Y, Burgess TL, Dussault I, Kim TS. Design, synthesis, and biological evaluation of potent c-Met inhibitors. J Med Chem. 2008 Sep 25;51(18):5766-79. PMID:18763753 doi:10.1021/jm8006189

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