3c2i

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Template:STRUCTURE 3c2i

Contents 1 The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF 2 Disease 3 About this Structure 4 Reference

The Crystal Structure of Methyl-CpG Binding Domain of Human MeCP2 in Complex with a Methylated DNA Sequence from BDNF

Template:ABSTRACT PUBMED 18313390

Disease

Known disease associated with this structure: Angelman syndrome OMIM:[300005], Encephalopathy, neonatal severe OMIM:[300005], Mental retardation, X-linked, Lubs type OMIM:[300005], Mental retardation, X-linked, syndromic 13 OMIM:[300005], Rett syndrome OMIM:[300005], Rett syndrome, preserved speech variant OMIM:[300005], Autism, susceptibility to, X-linked-3 OMIM:[300005]

About this Structure

3C2I is a 3 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Ho KL, McNae IW, Schmiedeberg L, Klose RJ, Bird AP, Walkinshaw MD. MeCP2 binding to DNA depends upon hydration at methyl-CpG. Mol Cell. 2008 Feb 29;29(4):525-31. PMID:18313390 doi:10.1016/j.molcel.2007.12.028

Page seeded by OCA on Tue Feb 17 11:31:25 2009