2cvq

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Image:2cvq.png

Template:STRUCTURE 2cvq

Crystal structure of NAD(H)-dependent malate dehydrogenase complexed with NADPH

Template:ABSTRACT PUBMED 16009341

About this Structure

2CVQ is a 2 chains structure of sequences from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

  • Tomita T, Fushinobu S, Kuzuyama T, Nishiyama M. Crystal structure of NAD-dependent malate dehydrogenase complexed with NADP(H). Biochem Biophys Res Commun. 2005 Aug 26;334(2):613-8. PMID:16009341 doi:10.1016/j.bbrc.2005.06.133
  • Kelly CA, Nishiyama M, Ohnishi Y, Beppu T, Birktoft JJ. Determinants of protein thermostability observed in the 1.9-A crystal structure of malate dehydrogenase from the thermophilic bacterium Thermus flavus. Biochemistry. 1993 Apr 20;32(15):3913-22. PMID:8471603
  • Kelly CA, Sarfaty S, Nishiyama M, Beppu T, Birktoft JJ. Preliminary X-ray diffraction analysis of a crystallizable mutant of malate dehydrogenase from the thermophile Thermus flavus. J Mol Biol. 1991 Sep 20;221(2):383-5. PMID:1920425
  • Birktoft JJ, Rhodes G, Banaszak LJ. Refined crystal structure of cytoplasmic malate dehydrogenase at 2.5-A resolution. Biochemistry. 1989 Jul 11;28(14):6065-81. PMID:2775751
  • Nishiyama M, Matsubara N, Yamamoto K, Iijima S, Uozumi T, Beppu T. Nucleotide sequence of the malate dehydrogenase gene of Thermus flavus and its mutation directing an increase in enzyme activity. J Biol Chem. 1986 Oct 25;261(30):14178-83. PMID:3771528
  • Birktoft JJ, Banaszak LJ. The presence of a histidine-aspartic acid pair in the active site of 2-hydroxyacid dehydrogenases. X-ray refinement of cytoplasmic malate dehydrogenase. J Biol Chem. 1983 Jan 10;258(1):472-82. PMID:6848515

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