1dan
From Proteopedia
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Complex Of Active Site Inhibited Human Blood Coagulation Factor Viia With Human Recombinant Soluble Tissue Factor
Bound ligands : BGC,CA,CAC,CGU,CH2,CL,DPN,FUC
Contents |
Overview
Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for understanding many, molecular aspects of the initiation of coagulation.
Disease
Coagulation Factor Iii; F3 OMIM:134390
Myocardial infarction, decreasedsusceptibility to OMIM:227500
Gene Ontology Information
Related Structures
by homologous chain: 1JPS, 1KLI, 1YGC, 1Z6J
Links
1dan at OCA
This structure was featured in Molecule of the Month pdb75
References
- Primary: Banner DW, D'Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D "The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor." Nature 1996 Mar 7;380(6569):41-6. PMID:8598903
Page seeded by OCA on Thu Oct 25 09:31:08 2007
Categories: D.W.Banner | BGC | CA | CAC | CGU | CH2 | CL | DPN | FUC | F3 (Gene) | F7 (Gene) | Coagulation Factor Iii (Disease) | Myocardial infarction (Disease) | Homo sapiens | H: (SCOP Domain) | L:1-48 (SCOP Domain) | L:49-86 (SCOP Domain) | L:87-142 (SCOP Domain) | T:,U:91-106 (SCOP Domain) | U:107-210 (SCOP Domain) | 49267 (SCOP Family) | 50550 (SCOP Family) | 57201 (SCOP Family) | 57632 (SCOP Family) | 49266 (SCOP SuperFamily) | 50514 (SCOP SuperFamily) | 57197 (SCOP SuperFamily) | 57631 (SCOP SuperFamily) | 48725 (SCOP Fold) | 50493 (SCOP Fold) | 57015 (SCOP Fold) | 57629 (SCOP Fold) | 48724 (SCOP Class) | 56992 (SCOP Class)
