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spinqualitylabelsall models PDB ID 1r0p Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
1r0p, resolution 1.80Å ()
Ligands:
Gene:	MET (Homo sapiens)
Activity:	Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2
Structural annotation: Resources: CATH : 1R0Pa01, 1R0Pa02 InterPro : Ipr001245, Ipr002165, Ipr001627, Ipr000719, Ipr014756, Ipr008266, Ipr011009, Ipr002909, Ipr003659 Pfam : PF07714 SCOP : d1r0pa_ UniProt : P08581
Functional annotation: Cellular component: membrane fraction integral to plasma membrane membrane integral to membrane basal plasma membrane Biological process: myoblast proliferation muscle development hepatocyte growth factor receptor signaling pathway cell proliferation protein amino acid phosphorylation signal transduction activation of MAPK activity adult behavior brain development multicellular organismal development protein amino acid autophosphorylation cell surface receptor linked signal transduction Molecular function: hepatocyte growth factor receptor activity receptor activity nucleotide binding protein-tyrosine kinase activity kinase activity protein kinase activity protein binding transferase activity ATP binding
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Contents 1 Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a 2 Disease 3 About this Structure 4 Reference

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a

Template:ABSTRACT PUBMED 14559966

Disease

Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]

About this Structure

1R0P is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12654-9. Epub 2003 Oct 14. PMID:14559966 doi:10.1073/pnas.1734128100

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