1dan
From Proteopedia
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Complex Of Active Site Inhibited Human Blood Coagulation Factor Viia With Human Recombinant Soluble Tissue Factor
Contents |
Overview
Blood coagulation is initiated when tissue factor binds to coagulation, factor VIIa to give an enzymatically active complex which then activates, factors IX and X, leading to thrombin generation and clot formation. We, have determined the crystal structure at 2.0-A degrees resolution of, active-site-inhibited factor VIIa complexed with the cleaved extracellular, domain of tissue factor. In the complex, factor VIIa adopts an extended, conformation. This structure provides a basis for understanding many, molecular aspects of the initiation of coagulation.
Functional features
Structural features
PDB entry information
Author: D.W.Banner
Crystal information
| length a | length b | length c | angle alpha | angle beta | angle gamma |
| 70.650 | 82.550 | 126.500 | 90.00 | 90.00 | 90.00 |
Related Structures
by homologous chain: 1JPS, 1KLI, 1YGC, 1Z6J
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