1sf1

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Image:1sf1.png

Template:STRUCTURE 1sf1

Contents

NMR STRUCTURE OF HUMAN INSULIN under Amyloidogenic Condition, 15 STRUCTURES

Template:ABSTRACT PUBMED 14988398

Disease

Known disease associated with this structure: Diabetes mellitus, rare form OMIM:[176730], Hyperproinsulinemia, familial OMIM:[176730], MODY, one form OMIM:[176730]

About this Structure

1SF1 is a 2 chains structure of sequences from Homo sapiens. Full experimental information is available from OCA.

Reference

  • Hua QX, Weiss MA. Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate. J Biol Chem. 2004 May 14;279(20):21449-60. Epub 2004 Feb 26. PMID:14988398 doi:10.1074/jbc.M314141200

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