2h8h

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Image:2h8h.png

Template:STRUCTURE 2h8h

Src kinase in complex with a quinazoline inhibitor

Template:ABSTRACT PUBMED 17064066

About this Structure

2H8H is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Hennequin LF, Allen J, Breed J, Curwen J, Fennell M, Green TP, Lambert-van der Brempt C, Morgentin R, Norman RA, Olivier A, Otterbein L, Ple PA, Warin N, Costello G. N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. J Med Chem. 2006 Nov 2;49(22):6465-88. PMID:17064066 doi:10.1021/jm060434q

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